Job Description

Our large pharmaceutical client is seeking an Associate Scientist to join their growing Biophysics & Molecular Attributes Group in Spring House, PA. The Biophysics & Molecular Attributes Group within Biologics Discovery uses innovative biophysical, biochemical, and mass spectrometry based analytical tools to help select best therapeutic candidates for clinical development. You will be a critical member of the Higher Order Structure (HOS) team that characterizes developability attributes like thermal stability, chemical stability, solubility, and aggregation on a broad range of biologics platforms including monoclonal antibodies, multi-specific antibodies, antibody drug conjugates, antibody radio conjugates, and other therapeutic proteins. You will design and perform experiments using a variety of technologies like HPLC, DSF, DSC, cIEF, GXII, DLS, and more.

Key Responsibilities:

• Execute automated methods for biophysical and structural characterization of antibody therapeutics. Integrate robotic liquid handling systems (e.g., Hamilton, Tecan) with analytical platforms to improve efficiency, consistency, and sample throughput.
• Execute analytical analysis of biologics candidates using a wide variety of technologies such as size-exclusion HPLC, plate-based HIC/Heparin binding, DSF.
• Evaluate results to deliver scientifically supported conclusions and recommendations that are documented in appropriate technical reports.
• Maintain lab and equipment.
• Collaborate with colleagues in the global organization to support discovery projects.
• Assist in developing recommendations for improving standard procedures.

Required Skills & Experience

• Master’s or Bachelor’s degree in a relevant scientific field
• 2 years of experience in protein characterization (biologics/large molecules)
• Hands-on expertise in using and troubleshooting analytical techniques such as HPLC, DSF, DSC, cIEF, GXII, and DLS for protein and antibody analysis

Nice to Have Skills & Experience

• Protein purification

Salary: $67,000 - $75,000 (can be flexible based off experience)

Hours: Monday-Friday, 8:00am-5:00pm

Hiring Method: Multiyear contract – After 1 year on contract, the individual will have the opportunity to apply for a permanent role or have their contract renewed for another year

PTO: 10 PTO days, 6 paid sick days & paid Holidays

Benefits: Medical, Dental, Vision and 401K plans available

Exact compensation may vary based on several factors, including skills, experience, and education. Benefit packages for this role will start on the 31st day of employment and include medical, dental, and vision insurance, as well as HSA, FSA, and DCFSA account options, and 401k retirement account access with employer matching. Employees in this role are also entitled to paid sick leave and/or other paid time off as provided by applicable law.

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